Table 2.
Frequencies of most prevalent somatic mutations compared with TCGA data.
| Mutation Pattern | In this study of 275 patients (195 harbouring somatic mutation |
In TCGA data (n=507) |
||
|---|---|---|---|---|
| # patients | Percentage | # patients | Percentage | |
| Mutation in gene | ||||
| AKT1 | 6 | 3 | 23 | 4.5 |
| PIK3CA | 82 | 42 | 179 | 35.3 |
| PTEN | 25 | 12.8 | 16 | 3.2 |
| TP53 | 121 | 62 | 179 | 35.3 |
| Others | 16 | 8.2 | NA | NA |
| Mutation in single gene | ||||
| AKT1 | 2 | 1 | 9 | 1.8 |
| PIK3CA | 35 | 18 | 130 | 25.6 |
| PTEN | 4 | 2 | 6 | 1.2 |
| TP53 | 61 | 31 | 127 | 25.0 |
| Co-mutation in two genes | ||||
| AKT1+PIK3CA | 0 | 0.0 | 1 | 0.2 |
| AKT1+PTEN | 1 | 0.5 | 0 | 0.0 |
| AKT1+TP53 | 3 | 1.5 | 2 | 0.4 |
| PIK3CA+PTEN | 3 | 1.5 | 4 | 0.8 |
| PIK3CA+TP53 | 37 | 19 | 44 | 8.7 |
| PTEN+TP53 | 7 | 3.6 | 6 | 1.2 |
| PI3K + others | 43 | 22 | NA | NA |
| Co-mutation in three genes | ||||
| AKT1+PIK3CA+TP53 | 0 | 0.0 | 0 | 0.0 |
| PIK3CA+PTEN+TP53 | 1 | 0.5 | 0 | 0.0 |