Table 3.

Risk factors for SGLT2 inhibitor-associated DKA

Type 1 diabetes including latent autoimmune diabetes in adults (patients with presumed type 2 diabetes where there is clinical suspicion of type 1 diabetes should have autoantibodies tested)

Type 2 diabetes with insulin deficiency

Excessive reduction in exogenous insulin dose or insulin cessation

Diabetes due to pancreatic disease

Fasting, including during the perioperative state

Very low carbohydrate diet

Hypovolaemia

Excessive alcohol consumption (daily consumption and/or binge drinking)

Metabolic stress including acute infection, surgery, myocardial infarction, pancreatitis, and intensive exercise

DKA diabetic ketoacidosis, SGLT2 sodium-glucose cotransporter 2