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. 2020 Oct 22;10:18057. doi: 10.1038/s41598-020-75052-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prediction corrected visual predictive check (1000 samples) of the concentration–time data for LCIG and LECIG. The solid line is the median of the observed data. The dashed lines represent the observed 10th and 90th percentiles of the observations. The top and bottom light grey areas are the 95% confidence intervals for 10th and 90th percentiles of the simulated data. The middle dark grey area is the 95% confidence interval for the median of the simulated data.