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. 2020 Oct 22;10:18057. doi: 10.1038/s41598-020-75052-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Simulated plasma concentration for the study population, with unchanged patient doses of LCIG as reference (top left plot) and decreased continuous doses for LECIG treatment by: 0% lower morning dose and 35% lower maintenance dose (top right plot), 0% lower morning and maintenance dose (bottom left plot) and 20% lower morning and maintenance dose (bottom right plot). The solid line represents the median of the simulated data, the top and bottom dashed lines represent the 10th and 90th percentiles of the simulated data.