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. 2020 Oct 22;10:18020. doi: 10.1038/s41598-020-74798-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially methylated probes (DMPs) in peripheral blood T cells between AD patients and HC. (a) Venn diagram showing the overlap of DMPs in four different sorted T cell populations. Plotted with the open webtool venny 2.0 (https://bioinfogp.cnb.csic.es/tools/venny/). (b) Representative flow cytometry analysis of CD3, CLA, CD45RO and CCR4 in sorted CD4⁺CLA⁺ T cells. Numbers within quadrants represent percentage of cells. FSC-H: forward scatter height; in histogram solid black line: unstained; dotted line: isotype control; gray line: anti CCR4 staining. (c) Eight DMPs in CD4⁺CLA⁺ T cells. DNA methylation levels are expressed as M-values, gray bars indicate mean (bold), upper and lower (thin) quartiles. M values above 1 represent that the CpG site is methylated, and M values below − 1 represent that the CpG site is demethylated. Each dot represents an individual, HC (n = 9) and AD patients (n = 10). P_BH = Benjamini Hochberg p value.