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. 2020 Oct 22;10:18020. doi: 10.1038/s41598-020-74798-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed miRNAs in CD4⁺CLA⁺ T cells between AD patients and HC. (a) Differential miRNA expression by miRNA microarray between HC (n = 9) and AD patients (n = 10). Fold expression of 16 miRNAs with significant differences between AD patients and HC (Benjamini Hochberg corrected p value < 0.05). Blue indicates downregulation and yellow indicates upregulation. Each row corresponds to a miRNA and each column to 1 sample. Black and red squares on the top indicate HC and AD samples, respectively. Six down-regulated and 10 up-regulated and miRNAs in AD patients are indicated to the right of the heatmap. Software used Glucore Omics Explorer (https://www.qlucore.com/). (b) Log₂ miRNA levels from the microarray analysis between HC and AD patients. The array level indicates the amount of miRNA based on the fluorescence signal in the Cy3 channel. P_BH = Benjamini Hochberg p value. (c) ∆-Ct miRNA levels confirmed with qPCR between HC and AD patients. Gray bars in the panels B and C indicate mean (bold), upper and lower quartiles; each dot represents an individual.