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. 2020 Oct 22;10:18098. doi: 10.1038/s41598-020-75128-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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VCP involves in the alternative splicing of mitochondrial proteins under the stress. (a), (b) Representative LeafCutter cluster plots of the alternative splicing generated by LeafViz for the Ndufv3 (a) and Ndufs6 (b) in VCP TG vs WT at 2W TAC based on FDR < 0.05. Differential splicing was measured by the change in percent spliced in (dPSI). These two DETXs showed differential usage of a mutually exclusive exon between VCP TG and WT groups. (c), (d) Representative qRT-PCR results show the relative expression of splice isoforms by using two pairs of primers *: p < 0.05, n = 4/group.