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. Author manuscript; available in PMC: 2020 Oct 23.
Published in final edited form as: Histopathology. 2017 Dec 4;72(4):588–600. doi: 10.1111/his.13395

Figure 4:

Figure 4:

Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (SDH case #8, 34 year old male). The neoplasm has a nested, alveolar appearance (A) and is composed large pleomorphic cells with abundant eosinophilic cytoplasm. Multiple atypical mitotic figures are identified (B). Focally the neoplasm had a lower grade solid nested appearance (C) without diagnostic inclusions or cytoplasmic vacuoles. The neoplasm did demonstrate a peculiar globular staining pattern for cytokeratin (D). The neoplasm demonstrated loss of SDHB labeling (E), and presented with bony metastasis (F).