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Eosinophilic solid and cystic (ESC) renal cell carcinoma (ESC case #1, 15 year old male). The neoplasm is well delineated from the surrounded kidney (left), and contains both solid and cystic areas (A). The neoplasm has a solid nested architecture with multinucleate cells associated with the cystic spaces (B). At high power one can appreciate the flocculent, clumped nature of the cytoplasm (C). The neoplasm demonstrates patchy immunoreactivity for cytokeratin 20 (D).
