Table 3:
Eosinophilic Solid and Cystic Renal Cell Carcinoma
| Case | Age/Sex | Size/Stage | Notable pathologic features | Clinical history |
|---|---|---|---|---|
| ESC #1 | 15/M | Multifocal: 3.8 cm, 1.2 cm. pT1Nx (two left partial nephrectomies). Clinically bilateral. |
Focal Cathepsin K labeling | h/o brain tumor. No f/u available |
| ESC #2 | 30/F | 3 cm pT1Nx (partial nephrectomy) |
Cathepsin K negative | Presented with flank pain during pregnancy. No f/u available |
| ESC #3 | 28/F | 2.4 cm pT1Nx (partial nephrectomy) |
No h/o neoplasia or chemotherapy. No f/u available | |
| ESC #4 | 25/M | 5 cm pT1Nx (partial nephrectomy) |
Rare Cathepsin K positive cells | h/o” bladder carcinoma” at 16 months. No f/u available |
| ESC #5 | 15/F | Multifocal: 9 cm, 4cm pT4NxM1 |
Necrosis | Presented with inferior vena cava involvement and pulmonary emboli. Developed liver metastases 2 years later s/p chemotherapy. AWD x 72 months. No h/o neoplasia or genetic syndromes |
| ESC #6 | 26/F | Multifocal and cystic: 3.3 cm, 1 cm, 1 cm pT1cNxMx |
Cathepsin K positive | No f/u available |
| ESC #7 | 35/M | 1.3 cm pT1Nx |
Focally Cathepsin K positive | No f/u available |
| ESC #8 | 34/M | 2.2 cm pT1Nx |
Cathepsin K negative | No f/u available |
| ESC #9 | 32/F | 2.3 cm pT1Nx |
Cathepsin K negative | No f/u available |
| ESC #10 | 14/F | Multifocal and cystic: 8 cm, 4 cm, 2 cm, 0.5 cm. pT2NxMx |
Focally Cathepsin K positive | History of sickle cell trait NED x 4.5 months. No history of neoplasia or genetic syndrome. |
f/u= follow-up; h/o= history of; NED= no evidence of disease; AWD= alive with disease