Figure 2. Suggested Treatment Algorithms for Patients With Advanced Hepatocellular Carcinoma (HCC).

AFP indicates α-fetoprotein.

^aConsider lower starting dose of 200 mg and escalate as tolerated.

^bConsider starting dose-escalation strategy starting with 80-mg dose.

^cNot supported by level 1 evidence.

^dIf no prior programmed cell death-1 or programmed cell death ligand-1 failure.