Table 1.
Features of different breast cancer cell lines used in microgravity studies (modified from [41]).
| Cell Line | Tumor | Subtype | ER | PR | HER2 | Characteristic Expression |
|---|---|---|---|---|---|---|
| AU565 | AC | HER2 enriched | ‒ | ‒ | + | EGFR, HER3, HER4, p53 |
| BT-20 | IDC | Triple-negative | ‒ | ‒ | ‒ | Wnt-3, Wnt-7B |
| MCF-7 | IDC | Luminal A | + | + | ‒ | Wnt-7B, IGFBP2, -4, -5 |
| MDA-MB-231 | IDC | Claudin-low | ‒ | ‒ | ‒ | EGFR, TGFα, Wnt-7B |
| MDA-MB-468 | AC | Triple-negative | ‒ | ‒ | ‒ | EGFR, TGFα |
AC, adenocarcinoma; EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor; IDC, invasive ductal carcinoma; IGFBP, insulin-like growth factor-binding protein; TGFα, transforming growth factor alpha.