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. 2020 Oct 7;21(19):7391. doi: 10.3390/ijms21197391

Figure 6.

Figure 6

Combined injection of HAMC and WJ-MSC inhibits the mRNA expression of pro-inflammatory cytokine and matrix-degrading enzymes. (A) iNOS mRNA expression, (B) MMP-13 mRNA expression, (C) Adamts4 mRNA expression, and (D) Cox-2 mRNA expression. In the HAMC/WJ-MSCs-injected discs, mRNA expression of pro-inflammatory cytokine (inducible nitric oxide synthase; iNOS) and matrix-degrading enzymes, including MMP-13, A disintegrin and metalloproteinase with thrombospondin motifs 4 (Adamts4) and Cycloxygenase-2 (Cox-2) were found to be significantly downregulated compared to the vehicle-injected disc. Data are presented as mean ± SEM, one-way ANOVA followed by Tukey’s post-hoc test. (n = 3). For time, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as internal control. # p < 0.05, ## p < 0.01, ### p < 0.001 (vehicle vs.control), $ p < 0.05, $$$ p < 0.001 (HAMC vs. vehicle), ^ p < 0.05, ^^^ p < 0.001 (WJ-MSCs vs. vehicle only), * p < 0.05, ** p < 0.01, *** p < 0.001 (HAMC + WJ-MSCs vs. vehicle only).