Table 3.
Oncogenic or tumor-suppressive lncRNAs, circRNAs, and snoRNAs involved in the regulation of the epithelial-to-mesenchymal transition process.
| ncRNA | Tumor | Target Name | Mechanism of Action | References |
|---|---|---|---|---|
| Epithelial-to-mesenchymal transition | ||||
| onco-ncRNAs | ||||
| lncRNA LINC00645 ↑ | Glioma | miR-205-3p | Upregulation of ZEB1 | [123] |
| lncRNA MIR22HG ↑ | Glioblastoma | SFRP2 and PCDH15 | Producing miR-22-3p and miR-22-5p | [125] |
| lncRNA HOTAIR ↑ | Medulloblastoma | miR-206 | Upregulation of YY1 | [129] |
| circRNA MMP9 ↑ | Glioblastoma | miR-124 | Upregulation of CDK4 and AURKA | [127] |
| lncRNA ANRIL ↑ | Medulloblastoma | miR-323 | BRI3/CDK6 | [130] |
| antionco-ncRNAs | ||||
| lncRNA TCON ↓ | Glioblastoma | Smad2 and PKCα | Downregulation of Smad2 and PKCα possibly via complementary base pairing in mRNA | [124] |
| circRNA SMARCA5 ↓ | Glioblastoma | SRSF1 | Binds RNA binding proteins involved in splicing (e.g., SRSF1) | [128] |
| snoRNA SNORD47 ↓ | Glioblastoma | Unknown | Downregulation of N-cadherin | [112] |