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. 2020 Oct 8;21(19):7424. doi: 10.3390/ijms21197424

Figure 3.

Figure 3

Novel design approaches to improving CAR function. 3rd Gen CARs use two or more co-stimulatory tails to improve signalling outcomes (OX40, ICOS, CD3ε also used). KIR-CARs and NKG2D CARs leverage native TM interactions to constitutively recruit endogenous signaling modules DAP12 and DAP10, respectively. TCR-CAR uses a CD3ε-scFv fusion to harness the high number of ITAMs and regulatory sequences within all six CD3 tails. PDB codes of structures shown are: scFv: 3H3B, NKG2D ECD: 1MPU, TCR: 6XJR.