Table 2.
Antisense oligonucleotides designed and used to induce PRKN exon 3 skipping.
| AO Number | AO Nomenclature | Sequence 5′→3′ | Length (bp) |
|---|---|---|---|
| 1 | PRKN_H3A (+09 + 35) | AUGUGAACAAUGCUCUGCUGAUCCAGG | 27 |
| 2 | PRKN_H3A (+205 + 230) | CUGGUGGUGAGUCCUUCCUGCUGUCA | 26 |
| 3 | PRKN_H3A (−05 + 22) | UCUGCUGAUCCAGGUCACAAUUCUGUU | 27 |
| 4 | PRKN_H3A (−05 + 21) | AUUACCUGGACUUCCAGCUGGUGGUG | 26 |
| 5 | PRKN_H3A (+137 + 161) | CUGAGCUGCUGAGGUCCACCCGAGU | 25 |
| 6 | PRKN_H3A (+36 + 60) | ACCUUUUCUCCACGGUCUCUGCACA | 25 |
| 7 | PRKN_H3A (+62 + 86) | UCGCCUCCAGUUGCAUUCAUUUCUU | 25 |
| 8 | PRKN_H3A (+50 + 69) | CAUUUCUUGACCUUUUCUCC | 20 |
| 9 | PRKN_H3A (+55 + 81) | CCAGUUGCAUUCAUUUCUUGACCUUU | 26 |
| 10 | PRKN_H3A (+195 + 219) | GUCCUUCCUGCUGUCAGUGUGCAGA | 25 |
| 11 | PRKN_H3D (+05 − 20) | UCUUAGAGCAUUCCAAUUACCUGGA | 25 |
| 12 | PRKN_H3A (−17 + 09) | GUCACAAUUCUGUUUGGGAGCAAGGU | 26 |
| 13 | PRKN_H3A (+86 + 110) | GACGACCCCAGAAACGCGGCGGGAG | 25 |
| 14 | PRKN_H3A (+111 + 135) | GCUGUGAGCGGGAGCCCCAGAGCUU | 25 |
| 15 | PRKN_H3A (+162 + 186) | UCCUCCCAGGAGACUCUGUGGGGCU | 25 |