Figure 2.

Development of imiquimod-induced acute, chronic and resolved psoriasis-like dermatitis in mice skin. (A) Model timeline. (B) Representative macroscopic images of developed imiquimod-induced psoriasis-like dermatitis. (C) Graphical analysis of transepidermal water loss (TEWL) and erythema measurements in mice with acute, chronic and resolved psoriasis-like dermatitis. (D) Representative sections of psoriasis-induced mice skin stained with hematoxylin and eosin (scale bar = 100 µm, inset scale bar = 25 µm). (E) Graphical analysis of psoriasis-like mouse skin in acute, chronic and resolved groups comparing histological changes including epidermal thickness, rete peg length, dermal thickness and a total number of inflammatory cells per high-power field (HPF) (original magnification ×1000). Data are presented as mean ± SD. n = 8/group. ** p < 0.01, *** p < 0.001, ****p < 0.0001.