Figure 3.

Statistical analysis of proteomics expression for the CF patients compared with the healthy control subjects. A volcano plot between the Ctrl and CF groups shows the significantly dysregulated proteins (42 down-regulated and 22 up-regulated in the CF group), with cutoffs of 2 and 0.05 for the fold change (x-axes) and t-test, respectively (A). An orthogonal PLS-DA score plot with eight components indicates a significant separation between the study groups (Q2: 0.805, and R2: 0.971) for 1000 permutations due to the proteomics dysregulations (B).