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. 2020 Oct 4;21(19):7337. doi: 10.3390/ijms21197337

Figure 2.

Figure 2

The effects of Resv and exercise training (ET) markers of neuroinflammation. Treating 3xTg-AD mice with Resv or Resv with ET decreases the expression of key inflammatory markers. Corresponding densitometry measurements: A, wild-type (WT) mice; B, 3xTg-AD mice; C, 3xTg-AD mice + ET; D, 3xTg-AD mice + Resv; E, 3xTg-AD mice + Resv + ET. NF-κB, nuclear factor-kappa B; GFAP, glial fibrillary acidic protein; PARP, poly (ADP-ribose) polymerase; IRS-1, insulin-receptor substrate. AD, Alzheimer’s disease; ET, exercise training; Resv, resveratrol. Data are presented as mean ± SEM for 3 mice per group. *, compared to WT mice, p < 0.001; †, compared to 3xTg-AD mice, p < 0.001; ‡, compared to 3xTg-AD mice + ET, p < 0.05 for NF-κB.