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. 2020 Oct 4;21(19):7337. doi: 10.3390/ijms21197337

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effects of Resv and ET on the expression of markers of apoptosis. Treatment with Resv or Resv with ET decreased the expression of markers of apoptosis. Representative immunoblots show significant decreases in the expression of caspase 3, 7, 9, and Adam 10. Corresponding densitometry measurements: A, WT mice; B, 3xTg-AD mice; C, 3xTg-AD mice + ET; D, 3xTg-AD mice + Resv; E, 3xTg-AD mice + Resv + ET. Adam 10, disintegrin and metallopeptidase domain-containing protein 10. AD, Alzheimer’s disease; ET, exercise training; Resv, resveratrol. Data are presented as mean ± SEM for 3 mice per group. *, compared to WT mice, p < 0.05; ^†, compared to 3xTg-AD mice, p < 0.05; ^‡, compared to 3xTg-AD mice + ET, p < 0.05.