Skip to main content
. 2020 Oct 4;21(19):7337. doi: 10.3390/ijms21197337

Figure 6.

Figure 6

The effects of Resv and ET on the expression of markers of autophagy. Treatment with Resv or Resv with ET decreased protein expression of key autophagy markers. Autophagy was expressed using LC3-1 and Cathepsin B, Cathepsin D, and LAMP2 were measured as endolysosomal markers. Representative immunoblots show significant reductions in the expression of all markers with ET, Resv, and Resv with ET. The significant decrease in the expression p62 in brains of 3xTg-AD mice was prevented with Resv or Resv with ET. Corresponding densitometry measurements: A, WT mice; B, 3xTg-AD mice; C, 3xTg-AD mice+ET; D, 3xTg-AD mice + Resv; E, 3xTg-AD mice + Resv + ET. LAMP2, lysosomal-associated membrane protein; LC3-1, microtubule-associated protein 1 light chain 3 beta; p62, sequestosome 1/ubiquitin-binding protein. AD, Alzheimer’s disease; ET, exercise training; Resv, resveratrol. Data are presented as mean ± SEM for 3 mice per group. *, compared to WT mice, p < 0.05; †, compared to 3xTg-AD mice, p < 0.05; ‡, compared to 3xTg-AD mice + ET, p < 0.05.