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. 2020 Oct 4;21(19):7337. doi: 10.3390/ijms21197337

Figure 8.

Figure 8

The effects of Resv and ET on protein expression of SIRT1 and AMPK. Representative immunoblots show a significant decrease in the expression level of SIRT1 in 3xTg-AD mice. Treatment with Resv or Resv with ET increased the expression SIRT1. Expression levels of AMPK were not significantly different between groups. Corresponding densitometry measurements: A, WT mice; B, 3xTg-AD mice; C, 3xTg-AD mice + ET; D, 3xTg-AD mice + Resv; E, 3xTg-AD mice + Resv + ET. SIRT1, silent information regulator 1; AMPK, AMP-activated protein kinase. AD, Alzheimer’s disease; ET, exercise training; Resv, resveratrol. Data presented as mean ± SEM for 3 mice per group. *, compared to WT mice, p < 0.05; †, compared to 3xTg-AD mice, p < 0.05; ‡, compared to 3xTg-AD mice + ET, p < 0.05; #, p = 0.0578 compared to WT mice.