Figure 1.

Macroscopic characterization of the heart of WT and MFS mice at 1, 2, and 3 months of age. Dot plot visualizes individual heart weight/tibia length ratios and mean value per age and genotype (n = 12 per age and genotype). WT and MFS measurements are indicated in grey and black, respectively. Error bars represent standard error. Associated p-values are annotated at the top of the graph (independent samples test on the mean values of the HW/TL). At the bottom of the figure, representative macroscopic pictures of WT and MFS mice hearts collected at 1, 2, and 3 months of age are depicted. Scale bar: 2 mm. HW/TL, heart weight to tibia length ratio (g/mm); WT, wild-type; MFS, Marfan syndrome.