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. 2020 Sep 24;21(19):7024. doi: 10.3390/ijms21197024

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Decreased compaction of the ventricular myocardial tissue in MFS mice correlates with a decreased presence of fibrillin-1 staining. (a,b): overview picture of fibrillin-1 (red) staining of myocardial tissue sections of a 3-month-old WT and MFS mouse, respectively. (c,d): representative overview pictures of HE-stained myocardial tissue sections of a 3-month-old WT and MFS mouse, respectively. (e): graphical presentation of the myocardial compaction level through the measurement of the average non-compaction index of the myocardial tissue sections (n/age group = 3). Within each age group, values are normalized to the WT values. WT and MFS measurements are indicated in grey and black, respectively. Error bars represents standard error. * p = 0.032 (independent samples test). RV, right ventricle; LV, left ventricle; WT, wild-type; MFS, Marfan syndrome. Scale bar = 500 µm.