Figure 2.

Schematic representation of STAT1 and STAT3 dimeric structure. The cartoon illustrates the proposed dimer conformations for STAT1 and STAT3 dimer: parallel and anti-parallel form. Phosphorylated STAT1 and STAT3 dimerize in parallel form by reciprocal interactions between phosphotyrosine residues and SH2D domains. Non-phosphorylated STAT1 and STAT3 dimers have an anti-parallel orientation of the bodies with SH2D domains on the opposite end of the dimers and the NTD domains lodged between monomer.