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STAT1 and STAT3 signaling pathway. Key steps of STAT1 and STAT3 signaling in response to cytokines. Binding of the ligands to the receptors induces receptor dimerization and activation of receptor associated JAK kinase, which in turn phosphorylates STAT1 and STAT3 proteins. Active STAT1/3 form dimer and translocate to the nucleus to control gene expression. The scheme focuses on the opposing roles of STAT1 and STAT3 transduction cascade.
