Table 2.
Kinetic parameters of the drug release mechanisms, where ‘n’ is the diffusion exponent, ‘kb’ is the initial burst constant, ‘θb’ is the contribution of initial burst release over total mass drug release, ‘kr’ is the rate of the degradation–relaxation constant, ‘kd’ is the diffusion kinetic constant and ‘tmax’ is the time to achieve a maximum rate of drug release derived from polymer degradation.
| Ѳb | kb (1/h) | Ѳr | kr (1/h) | tmax (h) | kd | n | |
|---|---|---|---|---|---|---|---|
| DOX_PHB in acid | 0.22 | 1.1 | 0.48 | 2.8 | 5.4 | 0.132 | 0.17 |
| DOX_PHB in plasma | 0.38 | 4.36 | 0.16 | 4.5 | 1.7 | 0.022 | 0.38 |
| DOX_PEG_PHB in acid | 0.26 | 9.6 | 0.35 | 4.4 | 2.1 | 0.137 | 0.19 |
| DOX PEG_PHB in plasma | 0.40 | 5.5 | 0.16 | >5.0 | 1.4 | 0.019 | 0.33 |
| SOR_PHB in acid | 0.29 | 2.5 | 0.70 | >1.3 | 6.0 | - | - |
| SOR_PHB in plasma | 0.98 | 7.9 | - | - | - | - | - |
| SOR_PEG_PHB in acid | 0.76 | 0.4 | 0.18 | 0.4 | 14.0 | - | - |
| SOR_PEG_PHB in plasma | 0.70 | >10.0 | 0.17 | 6.8 | 1.8 | - | - |