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. 2020 Oct 1;21(19):7265. doi: 10.3390/ijms21197265

Figure 1.

Figure 1

Cholesterol efflux mediated by apo AI and HDL2 in macrophages treated with non-glycated, AGE, control, DM 1 or DM 2 albumin. Bone marrow-derived macrophages (BMDMs) from C57BL/6 WT (n = 4) mice and Ager null (n = 4) mice were loaded with acetylated LDL (50 µg/mL) and 3H-cholesterol for 24 h. Cells were treated for 48 h with (A and B) control, DM 1 or DM 2 albumin or with (C and D) non-glycated or AGE albumin (1 mg/mL in DMEM). Apo A-I (30 µg/mL) or HDL2 ((50 µg/mL) were utilized as 3H-cholesterol acceptors in 6-h incubations. One-way ANOVA—Dunnett´s posttest; mean ± SD.