Table 1.
Putative Ori and Iru targets identified in both the cancer cell lines by mass spectrometry-based Drug Affinity Responsive Target Stability (DARTS) experiments.
| Protein (Swiss-Prot CODE) | MNK28 | A375 | ||
|---|---|---|---|---|
| ORI | IRU | ORI | IRU | |
| Alpha actin (ACTN1_HUMAN) | X | X | X | X |
| Heat shock cognate 70 (HSP74_HUMAN) | X | X | X | X |
| Nucleolin (NCL_HUMAN) | X | X | X | X |
| Ezrin (EZRI_HUMAN) | X | X | X | X |
| Heterogeneous nuclear ribonucleoprotein L (HNRL_HUMAN) | X | X | X | X |
| Alpha tubulin (TBA1B_HUMAN) | X | X | X | |
| Beta-enolase (ENOB_HUMAN) | X | X | X | X |
| Vinculin (VINC_HUMAN) | X | X | ||