Table 2.

Tdp 1 inhibiting activity (IC₅₀) of sulfonate berberine derivatives with polyfluoroaromatic substituents and their cytotoxicity (CC₅₀) in HeLa cells. Furamidine was used as a positive control (IC₅₀ = 1.2 ± 0.3 µM).

Code, structure	11e–h		12e–h
R	IC50, µM	CC50, µM	IC50, µM	CC50, µM
e;	>15	ND	>15	ND
f;	1.0 ± 0.20	11 ± 2.0	0.53 ± 0.01	9.9 ± 4.5
g;	1.05 ± 0.05	>100	1.3 ± 0.30	95 ± 5.0
h;	0.9 ± 0.20	2.6 ± 0.1	1.4 ± 0.30	2.2 ± 1.5