Table 4.
Peak areas of main absorbed constituents and their ratio between different administration groups (×106).
| 3,5-Dimethoxytoluene (M60) |
Safrole (M64) |
Methyleugenol (M79) |
2,3,5-Trimethoxytoluene (M82) |
3,4,5-Trimethoxytoluene (M83) |
Eugenol (M93) |
Kakuol (M138) |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | D | Ratio | P | D | Ratio | P | D | Ratio | P | D | Ratio | P | D | Ratio | P | D | Ratio | P | D | Ratio | |
| FE | 7.19 | n.d. | / | 3.25 | 0.0058 | 560.3 | 2.04 | 0.0052 | 392.3 | 3.45 | 0.005 | 690.0 | 4.07 | 0.01 | 407.0 | 0.10 | 0.02 | 5.4 | 1.36 | 0.70 | 1.9 |
| UR | 0.54 | n.d. | / | 0.04 | 0.0038 | 10.5 | 0.12 | 0.0064 | 18.8 | 0.65 | 0.030 | 21.7 | 1.10 | 0.32 | 3.4 | 5.66 | 6.58 | 0.9 | 16.79 | 10.51 | 1.6 |
| BL | 2.68 | n.d. | / | 2.54 | n.d. | / | 0.5 | n.d. | / | 1.91 | 0.032 | 59.7 | 2.11 | 0.31 | 6.8 | n.d. | n.d. | / | 0.10 | 0.02 | 6.4 |
| BR | 2.48 | n.d. | / | 1.94 | n.d. | / | 0.4 | n.d. | / | 0.75 | 0.007 | 107.1 | 0.64 | 0.06 | 10.7 | n.d. | n.d. | / | 0.07 | 0.01 | 13.0 |
| HE | 1.45 | n.d. | / | 0.98 | n.d. | / | 0.26 | n.d. | / | 0.54 | 0.007 | 77.1 | 0.46 | 0.05 | 9.2 | n.d. | 0.004 | / | 0.06 | 0.005 | 12.5 |
| LU | 1.27 | n.d. | / | 0.98 | n.d. | / | 0.24 | n.d. | / | 0.39 | 0.008 | 48.8 | 0.33 | 0.05 | 6.6 | 0.05 | 0.01 | 5.2 | 0.09 | 0.01 | 10.9 |
| SP | 1.86 | n.d. | / | 1.43 | 0.0004 | 3575.0 | 0.9 | 0.0016 | 562.5 | 0.97 | 0.009 | 107.8 | 0.59 | 0.06 | 9.8 | 0.02 | 0.01 | 3.0 | 0.16 | 0.01 | 21.7 |
| LI | 7.09 | 0.0017 | 4170.6 | 5.03 | 0.0012 | 4191.7 | 1.29 | 0.0032 | 403.1 | 2.26 | 0.031 | 72.9 | 1.89 | 0.24 | 7.9 | 0.05 | 0.02 | 2.6 | 0.05 | 0.04 | 1.2 |
| KI | 4.63 | 0.0019 | 2436.8 | 2.48 | 0.0018 | 1377.8 | 0.88 | 0.0051 | 172.5 | 2.58 | 0.056 | 46.1 | 2.78 | 0.56 | 5.0 | 0.22 | 0.23 | 0.9 | 1.13 | 0.31 | 3.6 |
| ST | 35.16 | 0.0025 | 14,064.0 | 46.54 | n.d. | / | 34.99 | 0.0801 | 436.8 | 18.84 | 0.293 | 64.3 | 17.07 | 1.90 | 9.0 | 0.20 | 0.05 | 4.1 | 8.58 | 2.36 | 3.6 |
| IN | 13.06 | 0.0021 | 6219.0 | 16.02 | 0.0025 | 6408.0 | 12.38 | 0.0069 | 1794.2 | 6.56 | 0.026 | 252.3 | 5.83 | 0.13 | 44.8 | 0.06 | 0.12 | 0.5 | 2.01 | 0.22 | 9.2 |
P: powder-treated group; D: decoction-treated group; FE: feces; UR: urine; BL: blood; BR: brain; HE: heart; LU: lung; SP: spleen; LI: liver; KI: kidney; ST: stomach; IN: small intestine. Ratio: the ratio of peak areas between powder- and decoction-treated groups. n.d.: not detected. /: The ratio cannot be calculated because the constituents failed to be detected in the powder- or decoction-treated group.