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. 2020 Sep 23;21(19):6985. doi: 10.3390/ijms21196985

Figure 2.

Figure 2

The PI3K/Akt signaling pathway converges to facilitate the progression OS. Most factors directly activate PI3K/Akt signaling pathway to promote the migration and invasion of OS. For example, overexpression of Fibulin-4, Fractalkine/CX3CR1, ZIC2, LINC0096, and lncRNA H19 promote the osteosarcoma metastasis through the activation of PI3K/Akt signal pathway. Meanwhile, GPNMB and DANCR/miR-33a-5p activate the PI3K/Akt pathway by promoting the expression of IGF-1 and AX, respectively. TSSC3 inhibits the phosphorylation of Src to activate the PI3K/Akt signaling pathway. Conversely, overexpression of LINC00628 inhibits the phosphorylation of PI3K and Akt. The solid lines refer to protein molecules and the dotted lines refer to non-coding RNAs in this figure. Black arrows show the promotion of molecules, while red dots show the inhibition of molecules.