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. 2020 Sep 23;21(19):6985. doi: 10.3390/ijms21196985

Table 2.

The hypoxia and acidosis in the bone microenvironment affect OS metastasis (↑: Up-regulation).

Physical Element Factors Interacting Molecule Efficacy Reference
Hypoxia HIF-1α CXCR4 migration ↑ [37]
TGF-β osteolytic bone metastases ↑ [40]
miR-20b invasion and proliferation ↑ [35]
miR-33b [41]
BMPR2 distant metastasis and poor survival rate ↑ [42]
LncRNA MALAT1 pro-angiogenic ↑ [43]
ANGPTL4 migration, proliferation ↑ [44]
HIF2PUT HIF2α distant metastasis ↑ [45]
Acidic condition CXCL1 growth, metastasis ↑ [31]
CXCL2
CXCL5
CXCR4
BMP2 colony formation ↑ [31]
CSF2/GM-CSF
CSF3/G-CSF
IL1A
IL1RN
IL23A
IL-6
IL-8
MMP2
NFκB1
RelA
RelB