Table 2.
Physical Element | Factors | Interacting Molecule | Efficacy | Reference |
---|---|---|---|---|
Hypoxia | HIF-1α | CXCR4 | migration ↑ | [37] |
TGF-β | osteolytic bone metastases ↑ | [40] | ||
miR-20b | invasion and proliferation ↑ | [35] | ||
miR-33b | [41] | |||
BMPR2 | distant metastasis and poor survival rate ↑ | [42] | ||
LncRNA MALAT1 | pro-angiogenic ↑ | [43] | ||
ANGPTL4 | migration, proliferation ↑ | [44] | ||
HIF2PUT | HIF2α | distant metastasis ↑ | [45] | |
Acidic condition | CXCL1 | growth, metastasis ↑ | [31] | |
CXCL2 | ||||
CXCL5 | ||||
CXCR4 | ||||
BMP2 | colony formation ↑ | [31] | ||
CSF2/GM-CSF | ||||
CSF3/G-CSF | ||||
IL1A | ||||
IL1RN | ||||
IL23A | ||||
IL-6 | ||||
IL-8 | ||||
MMP2 | ||||
NFκB1 | ||||
RelA | ||||
RelB |