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A summary diagram for the possible action of moscatilin on AGEs-treated SH-SY5Y cells. Moscatilin suppresses AGEs-induced RAGE expression by activating AMP-activated protein kinase (AMPK), thereby reducing intracellular formation ROS and NF-κB activation. These events subsequently alleviate mitochondrial dysfunction and finally result in reversing the mitochondrial apoptotic cascades associated with caspase-9 and -3 activation and the cleavage of PARP.
