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. 2020 Sep 24;21(19):7036. doi: 10.3390/ijms21197036

Figure 2.

Figure 2

Amino acid sequence alignment of melanocortin receptor 4 (MC4R) and melanocortin-2 receptor accessory protein 2 (MRAP2). (A) Amino acid alignment of tilapia MC4R (MT500790) with that of zebrafish (NP_775385), medaka (XP_004081243), chickens (NP_001026685), and humans (NP_005903). Horizontal lines mark the seven putative transmembrane domains (TMD1–7). Two N-glycosylation sites are underlined and highlighted in red. The DRY motif is highlighted with dark dots. (B) Alignment of tilapia MRAP2b (MT500791) with that of zebrafish (mrap2a: XP_001342923, mrap2b: XP_005168578), medaka (XP_004083625), chickens (NP_001307836) and humans (NP_612418). Horizontal line marks the transmembrane domains (TMD). An N-glycosylation site is underlined and highlighted in red. Dots/arrowheads indicate the residues conserved in MRAP2s across vertebrates. The three conserved regions in the long C-termini of vertebrate MRAP2s are indicated by dotted lines.