Table 1.

Sigma1R ligand with antidepressant properties.

Compound	Sigma1R Activity	Sigma1R Affinity, Ki
Fluvoxamine	Agonist [23,26,31,93,94,95,96]	36.0 nM [21] 17.0 nM [23]
Fluoxetine	Putative agonist [23,91,92,93,97]	240.0 nM 1 [21] 191.2 nM [23]
Sertraline	Putative antagonist Putative inverse agonist [91,92,93,94,98]	57.0 nM [21] 31.6 nM [23]
Escitalopram	Agonist [23,93]	288.3 nM [23]
Citalopram	Agonist [99]	292.0 nM [21] 403.8 nM [23]
Imipramine	Agonist [95,100,101,102]	343.0 nM [21] 332.1 nM [101]
DHEA	Agonist [103,104,105]	2.96 μM [106] 706.0 nM [107]
Igmesine (JO-1784)	Agonist [92,108]	75.0 nM [109]
Cutamesine (SA4503)	Agonist [93,110]	17.4 nM 2 [111]
Ketamine	Putative agonist [101,112]	139.6 μM 3 [101]

1 Ki for (±)-fluoxetine; 2 IC₅₀ 3 Ki for (±)-ketamine.