Figure 3.

Effects of PAI-1 during skeletal muscle regeneration. Induction of muscle damage results in the swift infiltration of immune cells (macrophages shown), resulting in the degradation of cellular debris and activation of satellite cells to form myoblasts. The activated myoblasts differentiate and fuse to form myotubes, which then mature within their niche to form complete myofibres. PAI-1 has been shown to inhibit the regeneration process at various levels (red bar lines), however the role of PAI-1 relating to satellite cell, myoblast and other cells (immune and fibrogenic cells) during regeneration has yet to be explored. Solid black arrows indicate activation. Red bars indicate inhibition or blockage.