Table 1.
Assembly factors required for maturation of Saccharomyces cerevisiae and human COX. The name of the gene represents it either being conserved in both organisms, only found in budding yeast (gene name/_) or only found in human (_/gene name).
| Mitochondrial Subunit | Transcription/mRNA Processing | Translation | Proteolytic Processing/Protease | Membrane Insertion | Copper Association | Haem Association | Chaperone | Unknown |
|---|---|---|---|---|---|---|---|---|
| COX1 | Cox24 | Mss51p/_ _/TACO1 |
Oma1 | Oxa1 Mba1/_ |
Cox11 Cox17 Cox19 Cox23 Cmc1 Cmc2 |
Coa2 Cox10 Cox15 Shy1/SURF1 |
Coa1/MITRAC15 Coa3/MITRAC12 Cox14 Mdj1 Ssc1 _/MITRAC7 |
|
| COX2 | – | Pet111 | Cox20 Imp1 Imp2 Som1 |
Oxa1 Cox18 Pnt1 Mss2 |
Cox16 Cox17 Cox19 Cox23 Coa6 Cmc1 Cmc2 Sco1 Sco2 _/TMEM177 |
– | Cox20 | |
| COX3 | – | Pet54 Pet122 Pet494 |
– | – | – | Rcf1p/HIGD2A | ||
| 2 or more genes | LRPPRC | – | – | – | – | – | ||
| Unknown | _/CEP89 _/COA7 _/COA8 Pet191/Coa5 |