Figure 1.

ECS delivery after cued reactivation does not disrupt reconsolidation of an auditory fear memory. (a) Schematic outline of experimental procedures used for the cue-ECS experiments. (b,e) Reactivation graphs indicate that all groups formed an aversive memory associated with the tone. (c,f) Post-reactivation long-term memory LTM (PR-LTM) graphs show no difference in freezing between the groups resulting from ECS treatment. (d,g) A within-subjects comparison showed no change in any group across days. (h–j) Modifying the duration of the reactivating tone and session prior to ECS does not result in amnesia either. *** p < 0.001, **** p < 0.0001, error bars = standard error of the mean (SEM). Horizontal bar = PR-LTM mean. “Pre-tone” is defined as the acclimation period during reactivation, prior to the tone presentation.