Figure 2.

ECS delivery after contextual reactivation does not disrupt reconsolidation of a contextual fear memory. (a) Schematic outline of experimental procedures for the context-ECS experiments. All animals acquired an aversive contextual memory, as measured at reactivation (b,e). PR-LTM freezing data for the male (c) and female (f) cohorts show no amnesia resulting from ECS. The ECS-imd and ECS-30m groups from the male cohort display significantly greater freezing than the sham group (c). A within-subjects comparison showed no change in any group across days (d,g). * p < 0.05, ** p < 0.01, **** p < 0.0001, error bars = SEM. Horizontal bar = PR-LTM mean. “Pre-training” is defined as the context acclimation period during training, prior to delivery of the tone-shock pairing.