Figure 4.

ECS may modestly impair extinction learning. (a) Schematic outline of experimental procedure testing the effects of ECS on extinction learning. (b) While both groups extinguish the fear memory, the sham group may extinguish the fear faster than the ECS group. This is indicated by a reduction in statistically significant differences between pre-training (baseline) and extinction session freezing. (c) Extinction data from (b) with baseline subtraction (extinction score) for the groups on each day indicate that the ECS group continues to show high levels of freezing across days, while the sham group displays a steady decrease to baseline freezing levels, such that the difference in fear extinction between the groups is significant at EXT 2, 3, and 5. * p < 0.05, ** p < 0.01, **** p < 0.0001, error bars = SEM. “Pre-training” is defined as the context acclimation period during training, prior to delivery of the tone-shock pairing.