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. 2020 Sep 23;25(19):4365. doi: 10.3390/molecules25194365

Scheme 6.

Scheme 6

Preparation of 2, 3 and 4-[18F]labeled phenylalanines via minimalist protocol; radiofluorination: elution of [18F]fluoride from the ion exchange cartridge with a solution of the MAI precursor (21 µmol) in 20% MeOH in DMF (0.6 mL); Cu(MeCN)4OTf (21 µmol) in DMF (0.6 mL), 85 °C, 20 min; hydrolysis: 12 M HCl (0.5 mL), 80 °C, 10 min [71].