Table 1.
Inhibitory effects (IC50 values ± SD) of the investigated compounds on cell growth of drug-sensitive CCRF-CEM and of multidrug-resistant CEM/ADR5000 cell lines.
| Compound | CCRF-CEM IC50 [µM] |
CEM/ADR5000 IC50 [µM] |
Degree of Resistance [a] | n |
|---|---|---|---|---|
| auranofin | 0.22 ± 0.08 | 0.28 ± 0.06 | 1.27 | 3 |
| Au(PEt3)Cl | 0.35 ± 0.03 | 0.26 ± 0.04 | 0.74 | 3 |
| Au(PEt3)Br | 0.28 ± 0.06 | 0.27 ± 0.05 | 0.96 | 3 |
| Au(PEt3)I | 0.32 ± 0.07 | 0.28 ± 0.08 | 0.87 | 3 |
| [Au(PEt3)2]Cl | 0.19 ± 0.06 | 0.23 ± 0.09 | 1.21 | 3 |
| Ag(PEt3)Cl | 1.36 ± 0.25 | 2.64 ± 0.48 | 1.94 | 3 |
| Ag(PEt3)Br | 1.50 ± 0.10 | 3.89 ± 0.70 | 2.59 | 3 |
| Ag(PEt3)I | 1.28 ± 0.12 | 1.46 ± 0.15 | 1.14 | 3 |
| [Ag(PEt3)2]NO3 | 1.39 ± 0.04 | 4.24 ± 0.05 | 3.05 | 3 |
[a] The degree of resistance was determined as the ratio of IC50 value of multidrug-resistant CEM/ADR5000 cells divided by the IC50 value of drug-sensitive CCRF-CEM cells; n = number of independent experiments with six replicates each.