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. 2020 Oct 22;10:18128. doi: 10.1038/s41598-020-75141-2

Figure 6.

Figure 6

Generation of advanced oxidation protein products (AOPPs) and ischaemia-modified albumin (IMA) in drug-induced liver injury. Upon exposure to drugs, the liver experiences oxidative stress. A series of pathophysiological events occur, particularly oxidative stress, mitochondrial damage, endoplasmic reticulum stress and bile salt export pump inhibition. Finally, AOPPs and IMA are generated.