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. 2020 Oct 22;10:17989. doi: 10.1038/s41598-020-75135-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of urine metabolome between vitiligo patients and healthy controls. (a) PCA analysis of urine metabolome. (SIMCA 14.0 software, Umetrics, Sweden) (b) Score plot of OPLS-DA model between vitiligo patients and healthy controls showed a better separation. (SIMCA 14.0 software, Umetrics, Sweden) (c) Pathway enrichment analysis showed significant enrichment (p < 0.05) of several pathways between the two groups. (MetaboAnalyst 3.0, https://www.metaboanalyst.ca) (d) A metabolites panel consisting of 7alpha-hydroxy-3-oxochol-4-en-24-oic acid, deoxyuridine, 3,4-octadienoylglycine, threoninyl-Proline showed the predictive ability with an AUC of 0.807 in the validation cohort. (MetaboAnalyst 3.0, https://www.metaboanalyst.ca).