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. 2020 Oct 22;10:17989. doi: 10.1038/s41598-020-75135-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of metabolic profiling in effective vitiligo self-control group. (a) Relative intensity of differential metabolites at different visits. (MetaboAnalyst 3.0, https://www.metaboanalyst.ca) (b) Sixteen of the metabolites showed a gradually increasing or decreasing trend with the improvement of the disease, with 8 gradually elevating and 8 gradually decreasing. (R package of pheatmap, R.3.4.2) (c–e) A panel consisting of 4-Methoxy-17beta-estradiol, dehydroepiandrosterone and cortexolone was used for predictive model construction using logistic regression. The ROCs were analyzed between baseline and first follow-up samples (c), baseline and second follow-up samples (d), baseline and third follow-up samples (e). (MetaboAnalyst 3.0, https://www.metaboanalyst.ca).