Table 2.
Origin and partial amino acid sequences of HA proteins of reassortant viruses.
Reassortant viruses | HA origins | Proteases | C-terminal amino acid sequences of HA1 |
---|---|---|---|
PR8 | A/Puerto Rico/8/34 (H1N1) | Trypsin | RSAKLRMVTGLRNIPSIQSR/ |
UT3040HA (R339G)/PR8 | A/Vietnam/UT3040/04 (H5N1) | Trypsin | KSNRLVLATGLRNSPQGER/RR/K/K/R/ |
UT3040HA (R339G)/PR8 | A/Vietnam/UT3040/04 (H5N1) | Furin | KSNRLVLATGLRNSPQGERRRKKR/ |
Multiple basic amino acids critical for CPP activity are shown in bold font. The underlined letters and slashes indicate the mutation site at position 339 and the predicted sites of proteolytic cleavage, respectively.