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. 2020 Oct 22;10:18051. doi: 10.1038/s41598-020-74650-4

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PRS results using discovery GWAS of 2594 mixed CHD cases and 5159 controls and SNPs with MAF ≥ 0.35. Plot shows odds ratio per standard deviation increase in PRS, with corresponding 95% confidence interval (CI). ‘P value threshold’ indicates that SNPs with discovery GWAS p values below the threshold were used for PRS construction. P_adj is the p value after correction for multiple correlated tests.