Table 7.

SKAT-O results of ultra-rare variants: ultra-rare variants are defined as MAF < 0.001 in gnomAD without variants missing in gnomAD to test whether the well-defined ultra-rare variants are driving the top rare results.

Gene	Locus	p value—WES	Variants tested	p value—WGS	Variants tested
ZNF318	chr6:43,336,070–43,369,647	8.07E−04	17	0.042	2

All genes were tested in the WES dataset; only the top-ranked genes (p < 0.001) were tested in the WGS dataset as a replication set.