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. 2020 Oct 8;21(19):7427. doi: 10.3390/ijms21197427

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Expression of miR-99a in early-stage breast cancer plasma. Distribution of circulating miR-99a levels in 125 plasma of early-stage breast cancer patients (stage I and II) and 193 healthy controls. Expression levels were significantly lower in healthy controls than in early-stage breast cancer patients. Horizontal line: median with interquartile range. Mann–Whitney U, **** p < 0.0001. (B) Receiver-operating characteristic (ROC) curve analysis for circulating miR-99a levels in early-stage breast cancer patients.